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An extreme close-up overhead shot of a gourmet Cajun Shrimp and Salmon dish, highlighting the texture and seasoning.

Cajun Shrimp and Salmon: A Flavor-Packed 30-Minute Meal

This one-pan Cajun Shrimp and Salmon recipe is ready in under 30 minutes! Tender salmon and succulent shrimp are coated in a spicy homemade Cajun seasoning and a savory garlic butter sauce for a quick, easy, and flavor-packed dinner.
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Prep Time 10 minutes
Cook Time 15 minutes
Total Time 25 minutes
Servings: 4 servings
Course: Dinner, Main Course
Cuisine: American, Cajun
Calories: 495
Ingredients Equipment Method Notes

Ingredients
  

  • 1.5 lbs salmon fillets skinless, cut into 4 equal portions
  • 1 lb jumbo shrimp peeled and deveined
  • 4 tbsp unsalted butter divided
  • 4 cloves garlic minced
  • 2 tbsp fresh lemon juice
  • 2 tbsp fresh parsley chopped, for garnish
  • 1 tbsp smoked paprika
  • 2 tsp garlic powder
  • 1 tsp onion powder
  • 1 tsp cayenne pepper adjust to taste
  • 1 tsp dried oregano
  • 1 tsp dried thyme
  • 1 tsp salt
  • 1/2 tsp black pepper

Equipment

  • 1 Large Skillet A cast-iron skillet works best for a great sear.
  • 1 Small Bowl

Method
 

  1. Pat the salmon fillets and shrimp completely dry with paper towels. In a small bowl, mix together all ingredients for the homemade Cajun seasoning: smoked paprika, garlic powder, onion powder, cayenne pepper, oregano, thyme, salt, and black pepper.
  2. Season the salmon and shrimp on all sides with the Cajun spice blend, pressing gently to make sure it sticks.
  3. Melt 2 tablespoons of butter in a large skillet over medium-high heat. Place the salmon fillets in the hot skillet and cook for 4-5 minutes per side, until golden brown and cooked through. Remove the salmon and set aside.
  4. Reduce heat to medium and add the remaining 2 tablespoons of butter to the skillet. Add the minced garlic and cook for 30 seconds until fragrant.
  5. Add the seasoned shrimp to the skillet in a single layer. Cook for 1-2 minutes per side, until pink and opaque. Do not overcook.
  6. Return the salmon to the skillet. Squeeze the fresh lemon juice over the shrimp and salmon, then sprinkle with chopped fresh parsley. Gently toss to coat everything in the garlic butter sauce. Serve immediately.

Notes

For the best sear, ensure your seafood is patted completely dry before seasoning.
Adjust the cayenne pepper in the seasoning blend to control the spice level.
Store leftovers in an airtight container in the refrigerator for up to 2 days.