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A close-up spoonful of creamy chicken biscuit bake, highlighting the tender chicken, mixed vegetables, and a piece of fluffy biscuit.

Chicken Biscuit Casserole (The Ultimate Comfort Food Recipe)

This Chicken Biscuit Casserole is the ultimate comfort food! A creamy chicken and vegetable filling is topped with fluffy, golden biscuits for an easy, family-friendly weeknight dinner.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 8 servings
Course: Dinner, Main Course
Cuisine: American
Calories: 450
Ingredients Equipment Method Notes

Ingredients
  

Main Ingredients
  • 4 tablespoons unsalted butter
  • 1 cup diced yellow onion
  • 1 cup diced celery
  • 1/4 cup all-purpose flour
  • 1.5 cups chicken broth
  • 1.5 cups whole milk
  • 3 cups cooked, shredded chicken rotisserie chicken works well
  • 2 cups frozen mixed vegetables thawed
  • 1.5 cups shredded sharp cheddar cheese
  • 1 teaspoon garlic powder
  • 1/2 teaspoon onion powder
  • 1/2 teaspoon dried thyme
  • 1/2 teaspoon salt or to taste
  • 1/4 teaspoon black pepper or to taste
  • 1 can refrigerated biscuits 16.3 oz, 8 count
  • 2 tablespoons unsalted butter melted
  • 1/4 teaspoon garlic powder

Equipment

  • 1 9x13 inch Baking Dish
  • 1 Large Skillet or Dutch Oven

Method
 

Instructions
  1. Preheat your oven to 375°F (190°C). Lightly grease a 9x13 inch baking dish.
  2. In a large skillet, melt 4 tablespoons of butter over medium heat. Add the diced onion and celery and cook until softened, about 5-7 minutes.
  3. Sprinkle the flour over the vegetables and stir for one minute.
  4. Slowly whisk in the chicken broth and milk until smooth. Bring to a simmer and cook for 3-5 minutes until thickened.
  5. Remove from heat. Stir in 1 tsp garlic powder, onion powder, thyme, salt, pepper, and shredded cheddar cheese until smooth.
  6. Gently fold in the shredded chicken and thawed mixed vegetables.
  7. Pour the mixture into the prepared baking dish.
  8. Cut each of the 8 biscuits into four pieces. Arrange the 32 pieces evenly over the filling.
  9. Mix 2 tablespoons of melted butter with 1/4 tsp of garlic powder. Brush this over the biscuit pieces.
  10. Bake for 25-30 minutes, or until the filling is bubbly and the biscuits are golden brown.
  11. Let the casserole rest for 5-10 minutes before serving.

Notes

For a golden-brown finish, you can broil the casserole for the last 1-2 minutes of cooking. Watch it carefully to prevent burning.
Using a rotisserie chicken is a great way to save time on meal prep.
Ensure your frozen vegetables are thawed to prevent excess water in the casserole and ensure even cooking.