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A close-up view of the creamy chicken casserole with biscuits, highlighting the tender chicken and mixed vegetables in a rich, savory sauce.

Chicken Biscuit Casserole (The Ultimate Comfort Food Recipe)

The ultimate Chicken Biscuit Casserole recipe! This easy, creamy bake features tender chicken and veggies topped with fluffy, cheesy biscuits for the perfect weeknight comfort food dinner that the whole family will love.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 8 servings
Course: Dinner, Main Course
Cuisine: American
Calories: 450
Ingredients Equipment Method Notes

Ingredients
  

  • 3 cups cooked shredded chicken rotisserie chicken works well
  • 1 can (10.5 oz) condensed cream of chicken soup
  • 1/2 cup milk
  • 1/2 cup sour cream
  • 2 cups frozen mixed vegetables thawed
  • 1 tsp garlic powder
  • 1/2 tsp onion powder
  • 1/2 tsp salt or to taste
  • 1/4 tsp black pepper or to taste
  • 1.5 cups shredded sharp cheddar cheese divided
  • 1 can (16.3 oz) refrigerated biscuits e.g., Pillsbury Grands!
  • 2 tbsp butter melted

Equipment

  • 1 9x13 inch Baking Dish
  • 1 Large Mixing Bowl

Method
 

  1. Preheat oven to 375°F (190°C). Lightly grease a 9x13-inch baking dish.
  2. In a large mixing bowl, combine the shredded chicken, thawed mixed vegetables, cream of chicken soup, milk, sour cream, garlic powder, onion powder, salt, pepper, and 1 cup of the shredded cheddar cheese. Stir until well combined.
  3. Pour the chicken mixture into the prepared baking dish and spread evenly.
  4. Separate the biscuits and arrange them in a single layer on top of the chicken mixture.
  5. Brush the tops of the biscuits with the melted butter.
  6. Sprinkle the remaining 1/2 cup of cheddar cheese over the biscuits.
  7. Bake for 25-30 minutes, or until the filling is bubbly and the biscuits are cooked through and golden brown.
  8. Remove from the oven and let it cool for 5-10 minutes before serving.

Notes

Shortcut Tip: Use a store-bought rotisserie chicken to save time on cooking and shredding chicken.
Storage: Store leftovers in an airtight container in the refrigerator for up to 3 days.
Variations: Feel free to add 1 cup of sautéed mushrooms or onions to the filling for extra flavor.