Get ready to transform your weeknight dinner routine with this incredibly flavorful Baked Cajun Salmon. This recipe delivers a perfectly flaky, moist, and tender salmon fillet with a zesty, smoky crust that’s simply irresistible. Forget complicated meals; this dish is on the table in under 20 minutes, making it the perfect solution for busy evenings when you crave something both healthy and delicious. It’s a restaurant-quality meal you can easily make in the comfort of your own kitchen.
We combine simple pantry staples to create a bold Cajun seasoning that perfectly complements the rich flavor of the salmon. The high-heat baking method locks in moisture, ensuring your salmon is never dry. Let’s dive in and make a dish that’s sure to become a new family favorite.

Why This Baked Cajun Salmon Recipe is a Must-Try
If you’re looking for a recipe that’s big on flavor but low on effort, you’ve found it. This Baked Cajun Salmon is a game-changer for quick and healthy meals.
- Quick & Easy: With just 5 minutes of prep and about 15 minutes in the oven, this is the ultimate fast meal.
- Healthy & Nutritious: Salmon is packed with omega-3 fatty acids, protein, and essential vitamins.
- Bold Flavor: The homemade Cajun spice blend brings a smoky, spicy, and savory kick that is absolutely addictive.
- Versatile: It pairs beautifully with a wide variety of side dishes, from roasted vegetables to creamy pasta.
The Stars of the Show: Key Ingredients
The magic of this dish lies in its simple yet powerful ingredients. You’ll need a good quality salmon fillet and a handful of spices that you likely already have in your pantry.
For the Salmon
- Salmon Fillets: Look for 4 center-cut salmon fillets, about 6 ounces each. Skin-on or skinless both work wonderfully for this recipe.
- Olive Oil: A little olive oil helps the seasonings adhere to the fish and promotes a beautiful crust.
For the Homemade Cajun Seasoning
While you can use a store-bought blend, making your own allows you to control the flavor and sodium levels. Simply mix these together:
- Smoked Paprika: Provides a deep, smoky color and flavor.
- Garlic Powder: For a savory, aromatic base.
- Onion Powder: Adds a subtle sweetness and depth.
- Dried Thyme: Brings an earthy, slightly minty note.
- Cayenne Pepper: This is where the heat comes from! Adjust the amount to your preferred spice level.
- Salt & Black Pepper: To enhance all the other flavors.

How to Make Baked Cajun Salmon (Step-by-Step)
Making this spicy salmon is as simple as season and bake. Follow these steps for perfect results.
- Preheat and Prepare: First, preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper for easy cleanup. Pat the salmon fillets completely dry with a paper towel—this is crucial for getting a nice crust.
- Season the Salmon: In a small bowl, whisk together the smoked paprika, garlic powder, onion powder, thyme, cayenne, salt, and pepper. Brush the salmon fillets lightly with olive oil. Then, sprinkle the Cajun seasoning generously over the top of each fillet, pressing gently to help it adhere.
- Bake to Perfection: Place the seasoned salmon fillets on the prepared baking sheet. Bake for 12-15 minutes. The exact time will depend on the thickness of your fillets. The salmon is done when it flakes easily with a fork.
- Serve Immediately: Serve the Baked Cajun Salmon hot, straight from the oven, with a squeeze of fresh lemon juice to brighten the flavors.
Pro-Tips for Perfect, Flaky Salmon Every Time
- Don’t Overbake: This is the most important tip! Salmon cooks quickly. Keep a close eye on it and check for doneness at the 12-minute mark. Overcooked salmon will be dry.
- Dry the Fish: Patting the salmon fillets dry with a paper towel before seasoning is a non-negotiable step. A dry surface allows the seasoning to stick better and helps the exterior to form a slight crust.
- Even Thickness: If possible, use salmon fillets that are similar in thickness to ensure they all cook at the same rate.
Delicious Serving Suggestions
This Baked Cajun Salmon is incredibly versatile. For a complete and satisfying meal, pair it with a side that complements its bold flavors. We love serving it with healthy sautéed vegetables for a low-carb option. It’s also fantastic with a scoop of creamy garlic parmesan orzo (coming soon) or alongside some crispy roasted cauliflower. For a heartier meal, try it with a simple green salad or fluffy quinoa.
Storing and Reheating Your Salmon
Store any leftover salmon in an airtight container in the refrigerator for up to 3 days. To reheat, it’s best to warm it gently in the oven at 300°F (150°C) for about 10 minutes or until warmed through. You can also flake the cold salmon and add it to salads or wraps for a delicious lunch, like this chicken bacon ranch wrap but with salmon!
Frequently Asked Questions
Yes, you can use frozen salmon. However, you must thaw it completely before cooking. Thaw it overnight in the refrigerator, then pat it completely dry with paper towels before seasoning and baking as directed.
Your salmon is done when it flakes easily with a fork at its thickest part. The internal temperature should read 145°F (63°C) on an instant-read thermometer, though many prefer to remove it closer to 135°F (57°C) for a more medium finish, as it will continue to cook slightly after being removed from the oven.
Properly stored in an airtight container, baked salmon will last for up to 3 days in the refrigerator. You can enjoy it cold on salads or gently reheat it in the oven.
This salmon is very versatile! It pairs wonderfully with roasted vegetables like asparagus or broccoli, a fresh green salad, quinoa, rice, or creamy garlic parmesan orzo. Anything that complements a bold, spicy flavor will work well.
The best temperature for baking salmon is 400°F (200°C). This high heat cooks the salmon quickly, keeping it moist and tender on the inside while helping to create a delicious crust on the outside.
Ready for More Flavor-Packed Dinners?
We hope you love this simple but spectacular Baked Cajun Salmon! It proves that you don’t need a lot of time to create a memorable meal. If this recipe sparked your culinary curiosity, we know you’ll be inspired by our other creations. Your feedback is our secret ingredient, so please leave a comment below or share your beautiful salmon dishes on Pinterest. Happy cooking!

Baked Cajun Salmon Recipe

Baked Cajun Salmon: A Flavorful Weeknight Delight
Ingredients
Equipment
Method
- Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper. Pat the salmon fillets completely dry with a paper towel.
- In a small bowl, whisk together the smoked paprika, garlic powder, onion powder, thyme, cayenne, salt, and pepper.
- Brush the salmon fillets lightly with olive oil. Sprinkle the Cajun seasoning generously over the top of each fillet, pressing gently to help it adhere.
- Place the seasoned salmon fillets on the prepared baking sheet. Bake for 12-15 minutes, or until the salmon flakes easily with a fork.
- Serve the Baked Cajun Salmon hot, with an optional squeeze of fresh lemon juice.
Notes
Customize the Heat: Feel free to increase or decrease the cayenne pepper to match your spice preference.




